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To achieve its goals, SyStemAge brings together a multidisciplinary consortium that builds on the most recent scientific achievements. It integrates a wide-range of technologies and expertise:

  • a strong link to the clinics with well established, ethical access to healthy donors and patient samples with well documented clinical history
  • an international network of experts in somatic stem cell biology, providing a battery of cellular and animal models for the study of senescence and assays for defining the activity of somatic stem cells (i.e. proliferative and differentiation potential)
  • access to state-of-the-art transcriptomics, proteomics and metabolomics for systems-wide and time-lapse quantification of the molecular changes associated with ageing as well as with the clinical course of age-related diseases
  • access to advanced resources in bioinformatics required to refine the biocomputational models and predictions: existing collections of large comparative genomics, epigenetics and transcriptomics datasets and expertise in the biology
  • access to the clinical expertise related to the treatment of MDS and B-CLL, as well as biological samples combined with records of the clinical courses of diseases from these patients
  • strong multidisciplinary computational and systems modelling approaches with proven record of successes in translational research
  • state-of-the-art biochemistry and phenotypic screening platforms based on innovative cellular co-culture assays together with libraries of bioactive compounds