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Anthony D. Ho
Anthony D. Ho received training in internal medicine and haematology-oncology at the University of Heidelberg. Since 1990 he has held leadership positions in Canada and U.S.A: "Full professor" at the University of Ottawa, Canada, (1990-1992), Co-Division Chief of Haematology-Oncology at the University of California, San Diego (1992-1998). Since April 1998 he has been Chair and Professor of the Department of Medicine V (Haematology, Oncology) at the Ruprecht-Karls University in Heidelberg. 425 Original Research Articles in peer-reviewed journals.
Anthony D. Ho's research focused on the characterization of molecular mechanisms of ageing and senescence of MSC and hHSC. His group has already shown strong differences in the characteristics and the global gene expression and methylation profiles of MSC upon replicative senescence, and MSC and hHSC from different age groups. Recently, they have shown that MSC of a different senescent state have different supportive potential on maintenance and proliferation of co-cultured hHSC, indicating changing properties within the niche upon ageing.
Role in SyStemAge:
Access to human primary material is one of the main contributions to the Consortium. Anthony D. Ho's group has established algorithms and infrastructures for:
- Collection and processing of marrow specimens derived from healthy human subjects of different age groups. (<20 , 20-40, 40-60, 60-70 and >70 years old).
- Isolation and purification of hHSC as well as subsets of other cell types, e.g. MSC, macrophages, lymphocyte, etc., from cord-blood, bone marrow from donors of different age groups.
- Co-Culture system of MSC and hHSC as surrogate model for the haematopoietic stem cell niche of “different ages”, and “cross-over” experiments.
- Protocols for MSC to be used for transcriptomics, proteomics analyses, (SILAC).
- Protocols for differential labelling (SILAC) of MSC and hHSC in co-culture systems.
- Correlation with clinical data.