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Prof. Toshio Suda while working with Prof. Makio Ogawa at Medical University of South Carolina, proposed a stochastic model in the differentiation of stem cells. This is evaluated as a classical work showing the independent differentiation of stem cells from the growth factors. Toshio Suda identified the niche for haematopoietic stem cells and subsequently established the new field of oxidative stress and stem cell ageing. The interaction of normal and leukemic stem cells and niche is one of hot topics for the stem cell biology. Toshio Suda is an MD from Yokohama City University School of Medicine. He was Professor of the Department of Cell Differentiation at Kumamoto University School of Medicine, then he was Professor of Development Biology at Keio University. As of1st of April 2015, Professor Toshio Suda is a Senior Principal Investigator at Cancer Science Institute of Singapore and Professor at the Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore.
Role in SyStemAge:
DNA damage. Prof. Toshio Suda's group has established an ataxia telangiectasia mutated (ATM) floxed model and found that deficiency of ATM genes induced the precocious ageing of HSCs and abnormal angiogenesis. This group also showed that telomerase reverse transcriptase (TERT) exerted telomere-independent activity and regulated HSC and EC replication. It is likely that the genome instability associated with ATM- or Tert-deficiency represents a leading cause for the development of leukaemia and lymphoma. The group plans to extensively measure the accumulation of DNA damage responses in HSCs of normal, ATM-/-and TERT-/- mice using γH2AX and the comet assay after anti-cancer drugs, irradiation and ageing. Moreover, his group has shown that ASPP-1 (p53 binding protein) deficient mice develop T-ALL after the accumulation of DNA damage in hematopoietic stem cells (HSCs). We will try to elucidate the relationship between aging and leukemogenesis.
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