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20 Mar 2017
Cordis gives you all the necessary information about all EU-funded research projects and project results since 1990. You can search and have an access to a detailed information of each EU project: funding, acronyms, dates, participants, summaries and reports. The information is provided based on the grant agreement and project's amendments (if any). You can read about SyStemAge project (dates, ...
10 Jan 2017
Project: Early warning signals of aging in human cells and age-related disorders Acronym: SyStemAge Project Coordinator: Dr. Anne-Claude Gavin Project Manager: Evgenia Belyaeva Funded under: FP 7 EU Area: Health and Innovation Relevant topic: Integrative systems biology and comparative genomics for studying human ageing and most common age-related diseases Grant Agreement No.: 306240 Start Date: ...
14 Dec 2016
We are delighted to introduce to you the third issue of our newsletter. Through this biannual electronic publication we hope to keep you informed about SyStemAge activities and to let you know what’s new in research. It’s been an active year for our project. Please check out all the exciting developments in our newsletter and on this SyStemAge website. We also encourage you to share our ...
5 Dec 2016
The majority of hematopoietic stem cells (HSCs) are maintained in a quiescent state to minimize premature exhaustion induced by various stresses. However, quiescent HSCs are vulnerable to mutagenesis because of attenuated DNA repair and DNA damage response programs. Basal abundant expression of prosurvival BCL-2 proteins further endows HSCs with high resistance to apoptosis. In contrast, HSCs ...
22 Aug 2016
Splicing factor gene mutations are the most frequent mutations found in patients with the myeloid malignancy myelodysplastic syndrome (MDS), suggesting that spliceosomal dysfunction plays a major role in disease pathogenesis. The aberrantly spliced target genes and deregulated cellular pathways associated with the commonly mutated splicing factor genes in MDS (SF3B1, SRSF2 and U2AF1) are being ...
16 Feb 2016
Amyotrophic Lateral Sclerosis is a fatal, progressive neurodegenerative disease characterized by loss of motor neuron function for which there is no effective treatment. One of the main difficulties in developing new therapies lies on the multiple events that contribute to motor neuron death in amyotrophic lateral sclerosis. Several pathological mechanisms have been identified as underlying ...
31 Aug 2015
Allogeneic stem cell transplantation (alloSCT) represents a curative therapeutic option for patients with myelodysplastic syndrome (MDS), but relapse and non-relapse mortality (NRM) limit treatment efficacy. Based on our previous observation in acute myeloid leukemia we investigated the impact of pre-transplant weight loss on post-transplant outcome in MDS patients. A total of 111 patients ...
20 Jul 2015
The field of angiogenesis research has primarily focused on the mechanisms of sprouting angiogenesis. Yet vascular networks formed by vessel sprouting subsequently undergo extensive vascular remodeling to form a functional and mature vasculature. This ‘‘trimming’’ includes distinct processes of vascular pruning, the regression of selected vascular branches. In some situations complete vascular ...
10 Apr 2015
Posttranslational modifications (PTMs) of proteins represent an important level of cellular control. They participate in the efficient transduction of signals and form the basis of long-term cellular memory, allowing cells to adapt to a rapidly changing environment. More than 200 different PTMs have been described that affect many aspects of protein functions, and the importance of these ...
1 Apr 2015
Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to a retrograde degenerative process or to a regenerative reaction, depending injury proximity among other factors. Distinguished key events associated with one or other processes may give some clues towards new ...

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