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1 Apr 2015
Considering pathological genetic variants within the context of the human interactome network can help understanding the intricate genotype-to-phenotype relationships behind human diseases. It allows, for instance, to distinguish between changes that totally suppress a gene product (i.e. node removal) from the ones that might affect only one of its functions, modulating the way in which the ...
15 Mar 2015
BACKGROUND: Cancer cell lines have a prominent role in the initial stages of drug discovery, facilitating high-throughput screening of potential drugs. However, their clinical relevance remains controversial. FINDINGS: We assess whether drug sensitivity in cancer cell lines is able to discriminate tissue specificity. We find that cancer-specific drugs do not show higher efficacies in cell lines ...
5 Jan 2015
Tissue homeostasis requires the presence of multipotent adult stem cells that are capable of efficient self-renewal and differentiation; some of these have been shown to exist in a dormant, or quiescent, cell cycle state. Such quiescence has been proposed as a fundamental property of hematopoietic stem cells (HSCs) in the adult bone marrow, acting to protect HSCs from functional exhaustion and ...
15 Dec 2014
Efforts to compile the phenotypic effects of drugs and environmental chemicals offer the opportunity to adopt a chemo-centric view of human health that does not require detailed mechanistic information. Here we consider thousands of chemicals and analyse the relationship of their structures with adverse and therapeutic responses. Our study includes molecules related to the aetiology of 934 health ...
27 Mar 2014
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3 Mar 2014
Under steady-state conditions most hematopoietic stem cells (HSC) remain quiescent within their stem cell niche and are rather resistant to oxidative stress. This ability to control the level of reactive oxygen species (ROS) is vital for preserving their self-renewal capacity and quiescence. Researchers from Keio and Hokkaido universities in Japan now found a key role for the mitochondrial heat ...
24 Feb 2014
Endothelial cells are often regarded as rather static cells forming a barrier at the inner lining of blood vessels. This view has recently been challenged by a study led by researchers of the DKFZ and the University of Heidelberg who have discovered a key regulatory role of the vascular endothelium in liver regeneration. Junhao Hu and Hellmut Augustin , who led the systematic study, identified a ...
12 Sep 2013
Researchers of the University of Oxford have identified a genetic signature that is significantly associated with survival of patients with blood disorders known as myelodysplastic syndromes (MDS). MDS is characterized by a loss of normal blood cell development and accumulation of defective blood cells in the bone marrow leading to development of acute myeloid leukemia (AML) in up to 40% of cases ...
21 Aug 2013
Welcome to the 1st newsletter of SyStemAge. The aim of this newsletter is to share project news and events within the consortium and the general public.
3 Jun 2013
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