Publication

10 Apr 2015
Posttranslational modifications (PTMs) of proteins represent an important level of cellular control. They participate in the efficient transduction of signals and form the basis of long-term cellular memory, allowing cells to adapt to a rapidly changing environment. More than 200 different PTMs have been described that affect many aspects of protein functions, and the importance of these ...
3 Mar 2014
Under steady-state conditions most hematopoietic stem cells (HSC) remain quiescent within their stem cell niche and are rather resistant to oxidative stress. This ability to control the level of reactive oxygen species (ROS) is vital for preserving their self-renewal capacity and quiescence. Researchers from Keio and Hokkaido universities in Japan now found a key role for the mitochondrial heat ...
24 Feb 2014
Endothelial cells are often regarded as rather static cells forming a barrier at the inner lining of blood vessels. This view has recently been challenged by a study led by researchers of the DKFZ and the University of Heidelberg who have discovered a key regulatory role of the vascular endothelium in liver regeneration. Junhao Hu and Hellmut Augustin , who led the systematic study, identified a ...
12 Sep 2013
Researchers of the University of Oxford have identified a genetic signature that is significantly associated with survival of patients with blood disorders known as myelodysplastic syndromes (MDS). MDS is characterized by a loss of normal blood cell development and accumulation of defective blood cells in the bone marrow leading to development of acute myeloid leukemia (AML) in up to 40% of cases ...

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