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Data integration and systems modelling (WP4)
The main goal of this WP is to integrate all the data generated within the consortium with those available in the literature in order to generate complex computational models that will provide a global view of the processes involved in HSC ageing, MDS and B-CLL. The main objectives are:
(1) Elucidation of the basic wiring of cellular processes related to somatic stem cell ageing.
(2) Transformation of the cell networks involved in HSC ageing and associated diseases into mathematical models (i.e. systems biology) in order to provide mechanistic descriptions.
(3) Identification of points of intervention with potential therapeutic value.