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Translation, therapy and drug discovery (WP5)
The overall objective of this WP is to translate the knowledge into guiding principles for new therapeutic strategies and drug discovery:
(1) Identification and preliminary characterization of hit compounds targeting age-related diseases by combining biochemical and cellular assay approaches.
(2) Establishment of novel 3D co-culture phenotypic assays for age-related diseases B-CLL and MDS.
(3) Bioinformatics prediction of mechanism of action, adverse effects and synergistic co-therapies of hit compounds.