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Systems biology of somatic stem cell ageing in the bone marrow (WP1)
The main scientific focus will be to define the molecular determinants and alterations associated with the physiology of somatic stem cell ageing in the bone marrow, using hematopoietic stem cells (HSC) as a model for somatic stem cells, and elements that constitute the bone marrow niche, comprising mesenchymal stromal cells (MSC), macrophages/monocytes, lymphocytes, and granulocytic as well as erythroid precursors. These subpopulations will be derived from healthy human subjects from different age groups. In addition to transcriptomics studies, WP1 will put special emphasis on novel proteomics analyses. Focus will be on the influence of environmental cues on the regulation of cellular ageing in adult stem cells.